Genetics and Ulcerative Colitis

There is evidence that Ulcerative Colitis may run in families. For a more thorough explanation of what genes are click here.

It has been shown through studies that people with Ulcerative Colitis should take a a daily low dose of folic acid and vitamin B12 in order to avoid complications from the MTHFR Gene Mutation This mutation has been proven to be a genetic cause of Ulcerative Colitis. “This study is the first to describe an association between the thermolabile MTHFR C677T variant and IBD (Intestinal Bowel Disease).

More Studies:

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The exact test “for homogeneity of odds ratios provided no evidence for heterogeneity between both populations (P = 0.35) and therefore confirmed the genetic associated between ulcerative colitis and the IL-1ra allele 2 in a different population. Our data confirm that, in ulcerative colitis, the presence of this allele is a genetic marker for severity of the disease.”

These results suggest that the IL-1 beta/IL-1Ra allelic cluster may participate in defining the biological basis of predisposition to chronic inflammatory bowel diseases.”

Cytokine interleukin-1 receptor antagonist

IgA Deficiency

loci on chromosomes 2 and 6 were linked in ulcerative colitis

Pubmed – If you are into the studies on Ulcerative Colitis search on this site. Do a search of your keywords at the top of the page.