Genetics and Ulcerative Colitis
There is evidence that Ulcerative Colitis may run in families. For a more thorough explanation of what genes are click here.
It has been shown through studies that people with Ulcerative Colitis should take a a daily low dose of folic acid and vitamin B12 in order to avoid complications from the MTHFR Gene Mutation This mutation has been proven to be a genetic cause of Ulcerative Colitis. “This study is the first to describe an association between the thermolabile MTHFR C677T variant and IBD (Intestinal Bowel Disease).
The exact test “for homogeneity of odds ratios provided no evidence for heterogeneity between both populations (P = 0.35) and therefore confirmed the genetic associated between ulcerative colitis and the IL-1ra allele 2 in a different population. Our data confirm that, in ulcerative colitis, the presence of this allele is a genetic marker for severity of the disease.”
“These results suggest that the IL-1 beta/IL-1Ra allelic cluster may participate in defining the biological basis of predisposition to chronic inflammatory bowel diseases.”
Pubmed – If you are into the studies on Ulcerative Colitis search on this site. Do a search of your keywords at the top of the page.