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A team of researchers from University of California, San Diego, have successfully used gut organoids in their lab to show the effects of medications to treat conditions such as “leaky gut”. The study was titled, “The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer,” and was published in the journal Life Science Alliance today.
Posted: February 10, 2020, 11:31 pm
Dr. Tim Denning, professor and associate director of the Institute for Biomedical Sciences at Georgia State University, has received a four-year, $1.67 million federal grant to study how an immunological pathway influences inflammatory signaling in the intestine that can lead to chronic human diseases such as inflammatory bowel disease.
Posted: February 9, 2020, 7:12 pm
Mucus is a protective, slimy secretion produced by goblet cells and which lines organs of the respiratory, digestive, and reproductive systems. Slime production is essential to health, and an imbalance can be life-threatening.
Posted: January 31, 2020, 12:21 pm
The cells that produce mucus are known to be involved in serious health conditions such as asthma, chronic obstructive pulmonary disease, and even cancer.
Posted: January 31, 2020, 10:35 am
Inflammatory bowel disease is a category of refractory inflammatory disease, of which ulcerative colitis and Crohn's disease are the main types.
Posted: January 21, 2020, 7:46 pm
Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn's disease (CD).
Posted: December 17, 2019, 6:41 am
Inflammatory bowel disease (IBD) is an umbrella term that describes many disorders that involve chronic inflammation of the digestive tract, including ulcerative colitis and Crohn's disease. These conditions are tied to certain alternations in the gut flora.
Posted: December 12, 2019, 9:31 pm
According to a new study published in the journal Gastroenterology, immune cells of a certain kind which regulate inflammatory processes and even help restore normal gut function after inflammation could be of great use to treat children with inflammatory bowel disease (IBD).
Posted: December 11, 2019, 10:29 pm
Chronic inflammatory bowel diseases, such as Crohn's Disease and ulcerative colitis, are linked to abnormalities of the gut microbiota in humans and in animals. Patients generally present reduced bacterial diversity in their intestinal flora along with excessive levels of bacteria that express a protein called flagellin, which favors their mobility.
Posted: December 11, 2019, 7:52 pm
Targeted immunization against bacterial flagellin, a protein that forms the appendage that enables bacterial mobility, can beneficially alter the intestinal microbiota, decreasing the bacteria's ability to cause inflammation and thus protecting against an array of chronic inflammatory diseases, according to a new study by the Institute for Biomedical Sciences and the Neuroscience Institute at Georgia State University.
Posted: December 11, 2019, 2:58 pm